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Acetaminophen and pyrilamine dan Dilantin-125

Penentuan interaksi Acetaminophen and pyrilamine dan Dilantin-125 dan kemungkinan penggunaannya secara bersamaan.

Hasil pengecekan:

Acetaminophen and pyrilamine <> Dilantin-125

Aktualitas: 20.04.2023 Pemeriksa: Dr. P.M.Shkutko, in

Dalam database direktori resmi yang digunakan saat membuat layanan, ditemukan interaksi yang tercatat secara statistik oleh hasil penelitian, yang dapat mengarah pada konsekuensi negatif bagi kesehatan pasien, atau meningkatkan efek positif yang saling menguntungkan. Konsultasi dengan dokter diperlukan untuk menjawab masalah penggunaan obat secara bersamaan.

Konsumen:

Menggunakan acetaminophen bersama dengan fenitoin dapat mengubah efek acetaminophen dan menyebabkan efek samping yang serius yang dapat mempengaruhi hati anda. Segera hubungi dokter anda jika anda mengalami demam, menggigil, nyeri sendi atau bengkak, kelelahan yang berlebihan atau kelemahan, perdarahan yang tidak biasa atau memar, ruam kulit atau gatal-gatal, kehilangan nafsu makan, mual, muntah, atau menguningnya kulit atau putih mata anda. Jika dokter anda tidak meresepkan obat-obat ini bersama-sama, anda mungkin memerlukan penyesuaian dosis atau tes khusus untuk aman mengambil kedua obat. Hal ini penting untuk memberitahu dokter anda tentang semua obat lain yang anda gunakan, termasuk vitamin dan rempah-rempah. Jangan berhenti menggunakan obat apapun tanpa terlebih dahulu berbicara dengan dokter anda.

Profesional:

MONITOR: Hydantoins dapat meningkatkan potensi hepatotoksisitas asetaminofen dan mengurangi efek farmakologis. Mekanisme yang mungkin terkait dengan induksi metabolisme asetaminofen dengan akibat peningkatan metabolit hepatotoksik. Interaksi ini adalah kekhawatiran terbesar dalam kasus-kasus overdosis acetaminophen.

MANAJEMEN: Monitoring fungsi hati dianjurkan. Pasien harus dianjurkan untuk menghindari dosis besar atau jangka panjang penggunaan acetaminophen.

Sumber

Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
Brackett CC, Bloch JD "Phenytoin as a possible cause of acetaminophen hepatotoxicity: Case report and review of the literature." Pharmacotherapy 20 (2000): 229-33
Bivins BA, Rapp RP, Griffen WO Jr, Blouin R, Bustrack J "Dopamine-phenytoin interaction. A cause of hypotension in the critically ill." Arch Surg 113 (1978): 245-9
Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH "Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects." J Clin Invest 63 (1979): 310-7
Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." Hum Toxicol 7 (1988): 33-4
Prescott LF, Critchley JA "Drug interactions affecting analgesic toxicity." Am J Med 75 (1983): 113-6

Acetaminophen and pyrilamine

Nama generik: acetaminophen / pyrilamine

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Sinonim: tidak

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