Pencarian obat berdasarkan namanya

Nefazodone Hydrochloride dan Prograf (Tacrolimus Granules for Suspension)

Penentuan interaksi Nefazodone Hydrochloride dan Prograf (Tacrolimus Granules for Suspension) dan kemungkinan penggunaannya secara bersamaan.

Hasil pengecekan:

Nefazodone Hydrochloride <> Prograf (Tacrolimus Granules for Suspension)

Aktualitas: 01.09.2022 Pemeriksa: Dr. P.M.Shkutko, in

Dalam database direktori resmi yang digunakan saat membuat layanan, ditemukan interaksi yang tercatat secara statistik oleh hasil penelitian, yang dapat mengarah pada konsekuensi negatif bagi kesehatan pasien, atau meningkatkan efek positif yang saling menguntungkan. Konsultasi dengan dokter diperlukan untuk menjawab masalah penggunaan obat secara bersamaan.

Konsumen:

Menggunakan tacrolimus bersama-sama dengan nefazodone dapat meningkatkan efek tacrolimus dan menyebabkan kerusakan pada ginjal atau menyebabkan saraf kehilangan. Beritahu dokter anda jika anda mengalami pusing, mati rasa, kesemutan kulit, otot berkedut, atau kejang yang mungkin menjadi tanda-tanda kerusakan saraf. Berbicara dengan dokter anda jika anda mengalami demam, menggigil, nyeri tubuh, gejala flu, dan sakit parah di perut bagian atas yang menyebar ke punggung anda. Jika anda mengambil obat-obatan bersama-sama, beritahu dokter anda jika anda memiliki gejala-gejala tersebut. Anda mungkin memerlukan penyesuaian dosis atau tes khusus jika anda menggunakan kedua obat-obatan. Hal ini penting untuk memberitahu dokter anda tentang semua obat lain yang anda gunakan, termasuk vitamin dan rempah-rempah. Jangan berhenti menggunakan obat apapun tanpa terlebih dahulu berbicara dengan dokter anda.

Profesional:

MEMONITOR: pemberian bersamaan dengan inhibitor poten dari CYP450 3A4 secara signifikan dapat meningkatkan konsentrasi darah dari tacrolimus, yang terutama dimetabolisme oleh isoenzim baik di usus dan hati. Ada banyak laporan dan studi farmakokinetik dalam literatur medis tacrolimus interaksi dengan berbagai ampuh CYP450 3A4 inhibitor, termasuk azole agen antijamur, antibiotik makrolida, dan protease inhibitor. Nefrotoksisitas dan efek samping lainnya (misalnya, hiperkalemia, hiperglikemia, anemia hemolitik, sindrom uremik hemolitik, neurotoksisitas) dalam hubungan dengan secara signifikan meningkat tacrolimus tingkat darah telah dilaporkan, sehingga perlu pengurangan substansial atau gangguan dalam tacrolimus dosis.

MANAJEMEN: hati-Hati disarankan ketika tacrolimus digunakan dengan ampuh CYP450 3A4 inhibitor. Dosis pengurangan dan/atau perpanjangan interval pemberian dosis untuk tacrolimus mungkin akan diperlukan. Pemantauan sering tacrolimus seluruh tingkat darah harus dilakukan selama dan setelah penghentian CYP450 3A4 inhibitor, dan tacrolimus dosis disesuaikan. Selain itu, pasien harus dipantau secara ketat untuk pengembangan efek samping yang serius seperti nefrotoksisitas, limfoma dan keganasan lainnya, infeksi, diabetes, neurotoksisitas (tremor, parestesia, ensefalopati, delirium, koma), hiperkalemia, perpanjangan QT, hipertrofi miokard, dan hipertensi. Pasien harus disarankan untuk mencari perhatian medis segera jika mereka mengalami gejala-gejala yang bisa menunjukkan terjadinya kabel tips de pointes seperti pusing, ringan, pingsan, palpitasi, irama jantung yang tidak teratur, sesak napas, atau sinkop.

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