Pencarian obat berdasarkan namanya

Altocor dan Luvox

Penentuan interaksi Altocor dan Luvox dan kemungkinan penggunaannya secara bersamaan.

Hasil pengecekan:

Altocor <> Luvox

Aktualitas: 19.07.2022 Pemeriksa: Dr. P.M.Shkutko, in

Dalam database direktori resmi yang digunakan saat membuat layanan, ditemukan interaksi yang tercatat secara statistik oleh hasil penelitian, yang dapat mengarah pada konsekuensi negatif bagi kesehatan pasien, atau meningkatkan efek positif yang saling menguntungkan. Konsultasi dengan dokter diperlukan untuk menjawab masalah penggunaan obat secara bersamaan.

Konsumen:

FluvoxaMINE dapat meningkatkan kadar lovastatin. Hal ini dapat meningkatkan risiko efek samping seperti kerusakan hati dan langka tapi serius kondisi yang disebut rhabdomyolysis yang melibatkan pemecahan jaringan otot rangka. Dalam beberapa kasus, rabdomiolisis dapat menyebabkan kerusakan ginjal dan bahkan kematian. Anda mungkin memerlukan penyesuaian dosis atau pemantauan lebih sering oleh dokter anda untuk dengan aman menggunakan obat-obatan. Biarkan dokter anda tahu segera jika anda tidak dapat dijelaskan, nyeri otot, nyeri, atau kelemahan saat mengambil obat-obat ini, terutama jika gejala ini disertai dengan demam atau urin berwarna gelap. Anda juga harus mencari perhatian medis segera jika anda mengalami demam, menggigil, nyeri sendi atau bengkak, perdarahan yang tidak biasa atau memar, ruam kulit, gatal-gatal, kehilangan nafsu makan, kelelahan, mual, muntah, urin berwarna gelap, dan/atau menguningnya kulit atau mata, ini mungkin tanda-tanda dan gejala kerusakan hati. Hal ini penting untuk memberitahu dokter anda tentang semua obat lain yang anda gunakan, termasuk vitamin dan rempah-rempah. Jangan berhenti menggunakan obat apapun tanpa terlebih dahulu berbicara dengan dokter anda.

Profesional:

MONITOR: pemberian bersamaan dengan inhibitor dari CYP450 3A4 dapat meningkatkan konsentrasi plasma dari HMG-CoA reduktase inhibitor (yaitu, statin) yang dimetabolisme oleh isoenzim. Lovastatin dan simvastatin sangat rentan karena mereka bioavailabilitas oral rendah, tetapi yang lain seperti atorvastatin, dan cerivastatin mungkin juga akan terpengaruh. Tingkat tinggi dari HMG-CoA reduktase aktivitas penghambatan dalam plasma dikaitkan dengan peningkatan risiko muskuloskeletal toksisitas. Miopati dinyatakan sebagai nyeri otot dan/atau kelemahan yang terkait dengan terlalu tinggi creatine kinase melebihi sepuluh kali batas atas normal telah dilaporkan kadang-kadang. Rhabdomyolysis juga jarang terjadi, yang dapat disertai dengan gagal ginjal akut sekunder untuk mioglobinuria dan dapat mengakibatkan kematian. Interaksi klinis yang signifikan telah dilaporkan dengan ampuh CYP450 3A4 inhibitor seperti antibiotik macrolide, azole antijamur, protease inhibitor dan nefazodone, dan moderat inhibitor seperti amiodarone, siklosporin, danazol, diltiazem dan verapamil.

MANAJEMEN: hati-Hati disarankan jika atorvastatin, cerivastatin, lovastatin, simvastatin, atau beras ragi merah (yang mengandung lovastatin) ditentukan dengan CYP450 3A4 inhibitor. Dianjurkan untuk memantau kadar lipid dan penggunaan yang efektif terendah statin dosis. Semua pasien yang menerima terapi statin harus disarankan untuk segera melaporkan tidak dapat dijelaskan, nyeri otot, nyeri atau kelemahan, terutama jika disertai dengan demam, malaise dan/atau urin berwarna gelap. Terapi harus dihentikan jika creatine kinase adalah nyata meningkat tanpa adanya latihan berat atau jika miopati adalah jika dicurigai atau didiagnosis. Fluvastatin, pravastatin, dan rosuvastatin tidak diharapkan untuk berinteraksi dengan CYP450 3A4 inhibitor.

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