Pencarian obat berdasarkan namanya

Indocin SR dan Pemetrexed Intravenous

Penentuan interaksi Indocin SR dan Pemetrexed Intravenous dan kemungkinan penggunaannya secara bersamaan.

Hasil pengecekan:

Indocin SR <> Pemetrexed Intravenous

Aktualitas: 14.09.2022 Pemeriksa: Dr. P.M.Shkutko, in

Dalam database direktori resmi yang digunakan saat membuat layanan, ditemukan interaksi yang tercatat secara statistik oleh hasil penelitian, yang dapat mengarah pada konsekuensi negatif bagi kesehatan pasien, atau meningkatkan efek positif yang saling menguntungkan. Konsultasi dengan dokter diperlukan untuk menjawab masalah penggunaan obat secara bersamaan.

Konsumen:

Menggunakan PEMEtrexed bersama dengan indometasin dapat meningkatkan efek PEMEtrexed. Hubungi dokter anda jika anda mengalami demam, menggigil, nyeri tubuh, gejala flu, mulut luka atau bercak putih, dan diare yang parah. PEMEtrexed dapat menurunkan sel-sel darah yang membantu tubuh anda melawan infeksi. Hal ini dapat membuatnya lebih mudah bagi anda untuk berdarah dari cedera atau sakit dari berada di sekitar orang lain yang sedang sakit. Untuk memastikan sel-sel darah tidak terlalu rendah, darah anda akan perlu diuji secara teratur. Jika dokter anda tidak meresepkan obat-obat ini bersama-sama, anda mungkin memerlukan penyesuaian dosis atau tes khusus untuk aman menggunakan kedua obat-obatan. Hal ini penting untuk memberitahu dokter anda tentang semua obat lain yang anda gunakan, termasuk vitamin dan rempah-rempah. Jangan berhenti menggunakan obat apapun tanpa terlebih dahulu berbicara dengan dokter anda.

Profesional:

MENYESUAIKAN DOSIS INTERVAL: pemberian bersamaan dengan obat anti-inflamasi nonsteroid (Nsaid) dapat meningkatkan konsentrasi plasma dari pemetrexed. Mekanisme belum dijelaskan, tetapi mungkin terkait dengan NSAID penghambatan prostaglandin ginjal. Penggunaan Nsaid telah dikaitkan dengan nefropati dimanifestasikan sebagai peningkatan dalam serum kreatinin dan BUN, nekrosis tubular, glomerulitis, ginjal nekrosis papiler, nefritis interstitial akut, sindrom nefrotik, dan gagal ginjal. Sejak pemetrexed adalah terutama dieliminasi tidak berubah oleh ginjal ekskresi, pemberian bersamaan dengan Nsaid dapat mengakibatkan keterlambatan dan/atau penurunan clearance. Harian ibuprofen dosis 400 mg empat kali sehari telah terbukti mengurangi pemetrexed clearance sekitar 20% pada pasien dengan fungsi ginjal normal, sedangkan aspirin pada 325 mg setiap 6 jam tidak. Efek dari dosis yang lebih tinggi dari ibuprofen atau aspirin adalah tidak diketahui.

MANAJEMEN: Ibuprofen 400 mg dan aspirin pada 325 mg empat kali sehari, atau kurang, dapat digunakan dengan pemetrexed pada pasien dengan fungsi ginjal normal. Namun, disarankan untuk hati-hati pada pasien dengan ringan sampai sedang insufisiensi ginjal (bersihan kreatinin 45 sampai 79 mL/menit). Pasien-pasien ini harus menghindari mengambil Nsaid dengan singkat eliminasi setengah-hidup (misalnya, diklofenak, etodolac, fenoprofen, flurbiprofen, ibuprofen, indometasin, ketoprofen, ketorolac, meclofenamate, asam mefenamat, sulindac, tolmetin, dosis rendah salisilat) 2 hari sebelum dan 2 hari setelah pemetrexed administrasi. Jika pemberian bersamaan diperlukan, pasien harus dipantau secara ketat untuk toksisitas, terutama myelosupresi, nefrotoksisitas, dan toksisitas gastrointestinal. Dengan tidak adanya data mengenai penggunaan bersama Nsaid dengan panjang setengah-hidup, menahan NSAID dosis selama setidaknya 5 hari sebelum sampai 2 hari setelah pemetrexed administrasi dianjurkan.

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